To determine whether any abnormal thrombotic screen results are due to either the Factor V Leiden G1691A or Prothrombin G20210A mutations. To determine if an extended PT is due to a deficiency in one of the extrinsic clotting factors. To determine if an extended APTT is due to a deficiency in one of the intrinsic clotting factors, or a clotting inhibitor. To identify if an extended APTT is potentially due to antiphospholipid antibodies. This test will automatically be added on if the laboratory staff suspect the presence of Disseminated Intravascular Coagulation (DIC).ĪPTT assay using phospholipid insensitive reagent
To determine the presence of D Dimer fibrin degradation products. To mechanically detect clot formation, for when a sample's plasma interferes with the analyser's optical clot detection method. Also, to determine if a mild G6PD deficiency is being masked by reticulocytosis. To determine red cell turnover and possible parasite haemolysis. To determine if the patient is glucose-6-phosphate dehydrogenase deficient, which may necessitate a change in the antimalarial therapy given. (More information about what is detected at PCH can be found under haematology test information) To determine if there is any haemoglobin S (HbS) present.Ĭonfirmation method to determine which haemoglobin variants are present. To test for haemoglobinopathies where blood film morphology and red cell indices are suggestive of the possibility. To test for the presence of heterophile antibodies that might indicate Infectious Mononucleosis, where blood film morphology and red cell indices are suggestive of the possibility. This may lead to further testing if the blood film is not conclusive by itself. To identify morphological features of blood cells when the FBC does not give sufficient information to be of clinical use. To determine red cell turnover and investigation of anaemia & haemolysis The Haematology laboratory has a supply of Sarstedt Thromboexact sample tubes for this purpose if it is deemed necessary for them to be used, then the laboratory should be contacted to arrange delivery. To obtain a correct platelet count for those patients whose platelets aggregate in standard ETDA-anticoagulated sample tubes. To prevent red blood cells from clumping together by warming the sample long enough for cold-reacting antibodies to lose adhesion. To correct the erroneously high haemoglobin concentration caused by interference from highly lipaemic plasma. To correct white blood cell counts (WBCs) that are higher than the analytical range of the analyser. To obtain correct results if the analyser incorrectly aspirates a sample, or requires further red cell indices such as a reticulocyte count or nucleated red cell count. For more information on any specific sendaway test, see the Haematology Test Information section. Some tests may require sending to external laboratories due to issues with specific samples, or analyser downtime. Unauthorised tests that are part of a set of requests made on a single form may also hold up the hard copy report of the results, but should not hold up electronic reporting. These will be performed as and when required by the laboratory staff, and are listed here for reference only. Below are listed sequential tests that may be required for appropriate results to be given, which may delay the release of the result of the initial test while they are being performed.
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